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The increasing prevalence of diabetes and obesity in western societies today makes these two diseases the leading epidemics of the 21st century. Closely linked with the development of serious complications, including cardiovascular disease and several malignancies, the morbidity and mortality associated with obesity and diabetes will continue to escalate as the population ages and becomes more sedentary. In Obesity and Diabetes, international experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity. The authors discuss in detail their diagnosis, clinical manifestations, complications, and best practices for diagnosis and treatment. They also review the history and epidemiology of these conditions, explain their genetics and pathophysiology, and illuminate their known mechanisms and interactions. State-of-the-art survey-chapters critique current approaches (lifestyle and pharmacological) to the treatment of these conditions. Authoritative and up-to-date, Obesity and Diabetes offers a comprehensive review of the scientific and clinical aspects of obesity and diabetes, even while providing a powerful incentive to focus our public health efforts on prevention and our clinical efforts on treatment.

Diabetes. --- Obesity. --- Diabetes --- Obesity --- Complications. --- Medicine. --- Endocrinology. --- Medicine & Public Health. --- Internal medicine --- Hormones --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Adiposity --- Corpulence --- Fatness --- Overweight --- Body weight --- Metabolism --- Nutrition disorders --- Diseases --- Disorders --- Complications and sequelae --- Endocrinology .

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Insulin --- Diabetes Mellitus --- therapeutic use --- drug therapy --- Diabetes --- Treatment --- Diabetes Mellitus. --- Diabetes. --- Insulin. --- therapeutic use. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Hormones --- Hypoglycemic agents --- Pancreas --- Proinsulin --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Diabetes Insipidus --- Glucose Intolerance --- Secretions --- Diseases --- Clinical Endocrinology

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This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant prot

Diabetes -- Genetic factors. --- Diabetes -- Pathophysiology. --- Diabetes Mellitus, Type 2. --- Transcription Factors. --- Diabetes Mellitus, Type 2 --- Diabetes Mellitus --- Glucose Metabolism Disorders --- Endocrine System Diseases --- Metabolic Diseases --- Diseases --- Nutritional and Metabolic Diseases --- Clinical Endocrinology --- Medicine --- Health & Biological Sciences --- Transcription factors. --- Diabetes --- Genetic factors. --- Pathophysiology. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Genetic transcription factors --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Proteins

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This volume examines the problem of the overweight individual and the metabolic syndrome from the laboratory bench to the bedside. Clearly, translating the findings we make in the laboratory to the betterment of humankind is an important mission. Areas where basic science is making important contributions to the problems associated with metabolic syndrome are illustrated in the chapters on Neuroendocrine Control of Food Intake, Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity, and Ectopic Fat and Metabolic Syndrome. For each of these, the fast-moving basic science area is opening new vistas for translation to the bedside and clinic. The larger segment of the book deals with the clinical context for the metabolic syndrome, central adiposity and overweight. The methods for measurement are well described and the application of these methods to evaluating patients and determining the prevalence in society is indicated. Genetic components of overweight and the metabolic syndrome are reviewed. The key role of visceral fat is emphasized by giving it a chapter of its own written by one of the foremost investigators of this problem. The importance of overweight and the metabolic syndrome in children is recognized in a separate chapter. There are a number of chapters focusing on treatment including behavioral therapy, exercise, diet, medications and surgery. In summary, this book is the alpha and omega of the overweight and metabolic syndrome problem. Series editor comments: Drs. Bray and Ryan have assembled a superb panel of authors who bring their expertise to this very timely book for medical practice. The epidemic of obesity is addressed in authoritative and cutting edge chapters ranging from the fundamental genetics and physiology of appetite control through the latest pharmacologic applications and surgical interventions. This is a "must have" volume for those treating patients with appetite disorders, obesity and diabetes, as well as those studying the intrinsic cellular and whole body pathogenesis of this modern population disorder. Shlomo Melmed, M.D. Series Editor Endocrine Updates.

Obesity. --- Metabolic syndrome. --- Cardiovascular syndrome, Metabolic --- Dysmetabolic syndrome X --- Insulin resistance syndrome --- Metabolic cardiovascular syndrome --- Metabolic syndrome X --- Insulin resistance --- Metabolism --- Syndromes --- Adiposity --- Corpulence --- Fatness --- Overweight --- Body weight --- Nutrition disorders --- Disorders --- Endocrinology. --- Metabolic diseases. --- Biochemistry. --- Diabetes. --- Metabolic Diseases. --- Medical Biochemistry. --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Internal medicine --- Hormones --- Composition --- Endocrinology . --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology

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L'obesità costituisce il problema nutrizionale più frequente nei paesi industrializzati. In Italia, un bambino su quattro è soprappeso, uno su dieci è obeso. Inoltre, i risultati di recenti indagini epidemiologiche suggeriscono che il numero dei bambini obesi sembra destinato ad aumentare ulteriormente. L'obesità esordita in età giovanile costituisce un problema soprattutto a causa di due fattori: la persistenza dell'obesità in età adulta e l'elevato rischio di morbilità: in più del 50% dei casi il bambino obeso mantiene il suo eccesso ponderale anche in età adulta; complicanze legate all'eccesso ponderale, quali l'intolleranza al glucosio ed il diabete, l'ipertensione arteriosa e le dislipidemie, un tempo proprie solo del soggetto obeso adulto sono riscontrabili in soggetti obesi già durante l'età evolutiva. L'estensione del fenomeno obesità ed il suo progressivo aggravarsi impongono la realizzazione di efficaci interventi preventivi e terapeutici. Questo volume riporta i più recenti aggiornamenti sui fattori genetici, metabolici e psicologici coinvolti nel determinare lo sviluppo dell'obesità nell'età evolutiva, e suggerimenti basati sull'evidenza scientifica per il suo trattamento.

Nutrition. --- Health. --- Personal health --- Wellness --- Medicine --- Physiology --- Diseases --- Holistic medicine --- Hygiene --- Well-being --- Alimentation --- Food --- Nutrition --- Health --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Health aspects --- Pediatrics. --- Medicine. --- Diabetes. --- Endocrinology. --- Psychology, clinical. --- Health Promotion and Disease Prevention. --- Clinical Psychology. --- Internal medicine --- Hormones --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Paediatrics --- Pediatric medicine --- Children --- Health and hygiene --- Health Workforce --- Health promotion. --- Endocrinology . --- Clinical psychology. --- Psychiatry --- Psychology, Applied --- Psychological tests --- Health promotion programs --- Health promotion services --- Promotion of health --- Wellness programs --- Preventive health services --- Health education